Beilstein J. Org. Chem.2017,13, 43–53, doi:10.3762/bjoc.13.6
) and ytterbium(III) further enhances the enantiomeric differentiation in the NMR spectra. The chiraldifferentiation with the phosphated cyclodextrins is compared to prior results obtained with anionic carboxymethylated cyclodextrins. There are a number of examples where a larger differentiation is
observed with the phosphated cyclodextrins.
Keywords: chiral; chiraldifferentiation; cyclodextrin; enantiomer; enantiomeric purity; NMR; Introduction
Chiral NMR solvating agents are commonly used for determining enantiomeric purity. In some cases, these compounds cause reproducible perturbations in
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Graphical Abstract
Figure 1:
Structure of cyclodextrins (CD) and their carboxymethylated (CM-CD) and phosphated (P-CD) derivativ...